For instance, it typically takes 4 hours for circulating plasma levels of scopolamine to even be detected once the patch is applied, and the time to reach peak levels averages 24 hours. The onset of pharmacological activity is very slow because of slow absorption of the drug through the intact skin. Patients with severe intractable chronic pain and those suffering relentless pain from a terminal illness who need but may not be able to tolerate high doses of oral opioids can benefit from the use of the transdermal fentanyl system.ĭespite the theoretical benefits of maintaining steady-state kinetics with the patch compared to the wide variations of blood levels, termed peaks and troughs, associated with oral administration of most drugs, the transdermal system of administration has numerous drawbacks. Likewise, nicotine patches are popular to help prevent signs and symptoms of nicotine withdrawal associated with acute cessation of cigarette smoking. The scopolamine patch is widely used for prevention of seasickness and is gaining popularity as an extra antinausea safeguard in select patients who need more than the traditional drugs such as ondansetron and dexamethasone to help prevent postoperative nausea and vomiting. The transdermal drug administration system, commonly known as “the patch,” is a convenient method to administer certain drugs that work best when steady therapeutic blood levels are maintained over time.
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